About CHLORO ACETYL CHLORIDE
Chloroacetyl chloride is an important chemical compound used primarily in organic synthesis Here are some key details about it
Chemical Information
IUPAC Name Chloroacetyl chloride
Chemical Formula C_2H_2Cl_2O
Molecular Weight Approximately 10299 gmol
Structure
Structure Description It consists of an acetyl group a carbonyl group linked to a methyl group with one of the hydrogens in the methyl group replaced by a chlorine atom The compound also contains an additional chlorine atom attached to the carbonyl group
Physical Properties
Appearance Chloroacetyl chloride is typically a colorless to pale yellow liquid
Boiling Point Around 97C 207F
Melting Point It is usually a liquid at room temperature so its melting point is not widely reported
Solubility It is soluble in organic solvents like ether and chloroform but reacts with water
Uses
Organic Synthesis It is used as an acylating agent in the synthesis of various organic compounds For example it can be used to introduce the acetyl chloride group into other molecules
Pharmaceuticals Its involved in the production of some pharmaceuticals and agrochemicals
Chemical Reactions Its often used in reactions to form acetylated products such as acetylated amino acids or other derivatives
Safety and Handling
Reactivity Chloroacetyl chloride is highly reactive especially with water where it forms acetic acid and hydrochloric acid This reaction is exothermic and should be handled with caution
Safety Precautions It is corrosive and can be harmful if inhaled ingested or if it comes into contact with skin or eyes Proper personal protective equipment PPE including gloves goggles and a lab coat should be used when handling this chemical
Storage It should be stored in a tightly sealed container in a cool dry place away from moisture and incompatible materials
If you need more specific details or have other questions about chloroacetyl chloride feel free to ask
Specialized Applications in Metabolic ResearchChloroacetyl chloride is primarily employed in laboratories to facilitate the study of metabolism of chloroacetamide herbicides, particularly using animal and human liver microsomes. Its unique properties make it suitable for identifying metabolic pathways, contributing to advancements in toxicology and pharmacology.
Key Physical and Chemical PropertiesThis liquid compound exhibits a high boiling point of 105C, a low melting point of -22C, and a density of 1.42 g/cm3. It reacts with water rather than dissolving, which is a crucial characteristic for laboratory safety and experimental controls.
Safe Handling and Storage RecommendationsDue to its reactivity and corrosive nature, chloroacetyl chloride must be stored in a dry, cool area, away from water sources and incompatible substances. Proper personal protective equipment is essential for handling, ensuring both safety and product integrity during use.
FAQ's of CHLORO ACETYL CHLORIDE:
Q: How should chloroacetyl chloride be stored and handled safely?
A: Chloroacetyl chloride must be stored in a dry, cool place away from water and moisture due to its reactive nature. When handling, always use appropriate protective gear including gloves, goggles, and lab coats, and work in a well-ventilated area or fume hood.
Q: What is the primary use of chloroacetyl chloride in laboratory research?
A: It is mainly used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes, helping researchers understand metabolic pathways and potential impacts of these herbicides.
Q: When is chloroacetyl chloride typically utilized during research processes?
A: Researchers use this compound during experimental phases that investigate how herbicides are metabolized in mammalian liver systems. It is especially relevant when analyzing metabolic profiles.
Q: Where can I source chloroacetyl chloride in India?
A: Chloroacetyl chloride is available through authorized suppliers, traders, and wholesalers across India. It is recommended to purchase from reputable sources to ensure quality and compliance with safety regulations.
Q: What benefits does chloroacetyl chloride offer in metabolic studies?
A: Its high reactivity and purity enable precise tracing of metabolic transformations, providing reliable results and improving understanding of herbicide breakdown in mammalian systems.
Q: What is the process of using chloroacetyl chloride in laboratory experiments?
A: Typically, it is introduced to reaction mixtures containing liver microsomes and herbicides under controlled conditions, facilitating metabolic reactions which are then analyzed for research insights.
Q: What precautions must be taken due to its solubility and reactivity?
A: Since chloroacetyl chloride reacts with water, it should never be mixed with aqueous solutions except under strictly controlled lab settings, and any accidental contact should be avoided to prevent hazardous reactions.